Levulan®Kerastick®

What is Levulan Kerastick used for?

The Levulan Kerastick for Topical Solution plus laser treatment (IPL or Vbeam) is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.

Who should NOT take Levulan?

Levulan Kerastick should not be taken by patients who have cutaneous photosensitivity at wavelengths at 400-450 nm, porphyria, or known allergies to porphyrins, and in patients with known sensitivity to any of the components of the Levulan Kerastick for Topical Solution.

Levulan Kerastick has not been tested on patients with inherited or acquired coagulation defects. There have been no formal studies of the interaction of Levulan Kerastick for Topical Solution with any other drugs and no drug-specific interactions were noted during any of the controlled clinical trials. It is possible that concomitant use of other known photosensitizing agents might increase the photosensitivity reaction of actinic keratoses treated with the Levulan Kerastick. It is important to tell your physician if you are taking any oral medications or using any topical prescription or non-prescription products on your face or scalp. Tell your doctor if you are pregnant or nursing.

What are the possible side effects?

The most common side effects include scaling/crusting, hypo/hyper-pigmentation, itching, stinging, and/or burning, erythema and edema. Severe stinging and/or burning at one or more lesions being treated was reported by at least 50% of patients at some time during the treatment.

What precautions should be taken?

Patients should avoid exposure of the photosensitive treatment sites to sunlight or bright indoor light prior to and at least 40 hours after blue light treatment. Exposure may result in a stinging and/or burning sensation and may cause erythema or edema of the lesions. Sunscreens will not protect against photosensitivity reactions caused by visible light.

Before Treatment Starts

Be sure to tell your physician if you are taking any oral medications or using any topical prescription or non-prescription products on your face or scalp.
Bring adequate sun-protective items with you to your appointment such as a wide-brimmed hat or umbrella.
The Levulan PDT Treatment

Treatment

A standard Microdermabrasion followed by Levulan will be uniformly applied to your AK lesions.

Your physician will direct you to wait one hour in order to allow the solution to penetrate the targeted cells. Then you will return for the second part of your treatment which includes illuminating your treated lesions with the either Vbeam or IPL laser.

Avoid exposing the treated lesions to sunlight and other forms of bright light for at least 40 hours. Examples include exam room examination lights, operating room lamps, tanning bed lights, and household lights at close range. Sunscreens will not protect against photosensitivity reactions caused by visible light during this time. Remember to wear light protective clothing, such as a wide-brimmed hat, during this time.

After Treatment

You may apply moisturizers as needed.

The most common side effects are:

Burning/stinging, which could be severe, may last up to 24 hours after your treatment
Redness and swelling which may last up to 4 weeks after your treatment
Scaling/crusting which may last up to 4 weeks after your treatment
General precaution for sun exposure

On a daily basis, always remember to use sunscreen and wear sun protective clothing to shield your skin from the sun’s damaging rays.